Home

Serositis in SLE

Serositis related to systemic lupus erythematosus

  1. At the time of serositis, 34 (92%) patients had active SLE in other systems. Nonsteroidal anti-inflammatory drugs (NSAIDs) were initially used in 13 (35%) patients. Moderate to high doses of oral prednisolone was used in 28 (76%) patients for both serositis and concomitant disease activity in other organs
  2. e the prevalence of serositis, its recurrence, management and complications in a large longitudinal cohort study
  3. Serositis is commonly seen in systemic lupus erythematosus (SLE). Approximately 16% of patients with SLE have pleural or pericardial involvement. However, peritoneal involvement is extremely rare, and clinically seen in a small group of patients
  4. al pain in..

Systemic lupus erythematosus (SLE) is an unusually complex autoim- Serositis in a 13-year-old boy with SLE. Contrast-enhanced CT scan shows bilateral pleural effusions ( ), cardiomegaly, and a pericardial effusion (arrow). Bilateral lower lobe atelectasis is also present A number of studies have noted marked elevation in some subsets of patients with active SLE. Lupus serositis is an example . In a series of lupus patients without infection, the median CRP level was 76 mg/liter in patients with serositis and only 16 mg/liter in those with exacerbations without serositis . Except for patients with serositis. Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that affects an estimated 5 million people worldwide. Various immune changes occur, including B cell lymphocyte hyperreactivity, T cell lymphocyte defects, complement activation, and autoantibodies to nuclear and cellular antigens. Serositis (pleuritis or pleural effusion.

Typically, vasculitis in SLE patients affects vessels that are less than 100 μm in diameter and is characterized by fibrinoid necrosis with marked wall thickening and minimal infiltration by inflammatory cells (, 2 4). This entity can occur in any organ system and can result in ischemia Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystem involvement. Although abnormalities in almost every aspect of the immune system have been found, the key defect is thought to result from a loss of self-tolerance to autoantigens

Most of the SLE cases are seropositive which depend on positive test for antinuclear antibody (ANA), Lupus erythematous (LE) cells, and antibody to DNA but seronegative SLE cases also rarely can present with complications SLE is more severe in children while in the elderly, it tends to be more insidious onset and has more pulmonary involvement and serositis and less Raynaud's, malar rash, nephritis, and neuropsychiatric complications Serositis is one of the cardinal findings in connective tissue diseases like systemic lupus erythematosus SLE is a chronic, multisystem, inflammatory connective tissue disorder of unknown cause that can involve joints, kidneys, serous surfaces, and vessel walls. It occurs predominantly in young women. Systemic Lupus Erythematosus (SLE) is an autoimmune disease, characterized by the production of a wide range of autoantibodies, resulting from polyclonal B cells activation, impaired apoptotic pathways, or idiotypic network dysregulation [1-5]. The anti-double stranded DNA antibodies (anti-dsDNA) are considered a specific marker for SLE

Serositis In Systemic Lupus Erythematosus: Prevalence

Serositis may present as painful or painless pleural, pericardial or ascitic fluid collections. However, only pleurisy and pericarditis are in the classification criteria. Serositis indicates inflammation of the lining of lung, heart and abdominal structures To explore the risk factors for systemic lupus erythematosus (SLE) flare and their impact on prognosis. The clinical characteristics, laboratory results, and treatment plans of 121 patients with SLE flare were retrospectively analyzed. Ninety-eight SLE outpatients with sustained remission during the same period were selected as controls Background/Purpose Serositis is one of both ACR and SLICC classification criteria for systemic lupus erythematosus (SLE) and a common type of extra renal flare. However, little is known about clinical or immunological associations of pleurisy or pericarditis Serositis, which refers to inflammation of serous membranes, does occur in SLE and may be a significant cause of morbidity. In light of the 1997 revised American College of Rheumatology (ACR) criteria, serositis refers either to pleuritis or to pericarditis [ 2 ] In general, cutaneous manifestations, musculoskeletal manifestations, and serositis represent milder disease, which may wax and wane with disease activity. These are often controlled with..

Background/Purpose Serositis is one of both ACR and SLICC classification criteria for systemic lupus erythematosus (SLE) and a common type of extra renal flare. However, little is known about clinical or immunological associations of pleurisy or pericarditis. The aim of this study is to analyze associates and predictors of pleurisy versus pericarditis in Caucasians and African Americans with SLE Prolactin and autoimmunity: hyperprolactinemia correlates with serositis and anemia in SLE patients. Orbach H, Zandman-Goddard G, Boaz M, Agmon-Levin N, Amital H, Szekanecz Z, Szucs G, Rovensky J, Kiss E, Doria A, Ghirardello A, Gomez-Arbesu J, Stojanovich L, Ingegnoli F, Meroni PL, Rozman B, Blank M, Shoenfeld Gastrointestinal (GI) manifestations are common in patients with systemic lupus erythematosus (SLE). William Osler, in 1895 [], was the first to emphasize that the GI manifestations may overshadow other aspects of the disease and mimic any type of abdominal condition.Anorexia, nausea and vomiting are seen in ∼50% of patients with SLE (see Table 1) [2- 5]; however, they may be due to the. Systemic lupus erythematosus (SLE) is a chronic multi-system disorder that most commonly affects women during their reproductive years. It is characterised by the presence of antinuclear antibodies. In addition to constitutional symptoms, it most frequently involves the skin and joints, although serositis, nephritis, haematological cytopenias. Systemic lupus erythematosus (SLE) is an autoimmune disease that affects the skin and musculoskeletal, renal, neuropsychiatric, hematologic, cardiovascular, pulmonary, and reproductive systems

Systemic lupus erythematosus (SLE) is the prototypical autoimmune disease, characterized by the presence of autoantibodies and multiorgan system involvement. Other organ system involvement can be painful, such as serositis (pleuritis or pericarditis). Neurologic system involvement may create painful peripheral neuropathy or headache. Clin Exp Dermatol 33:160-163 Serositis is a common manifestation and one of the diag- 3. Bakkaloflu A (2001) Lupus nephropathy in children. Nephron nostic criteria of systemic lupus erythematosus. The patho- Dial Transplant 16:126-128 genesis of serositis in SLE is considered to be a vasculitis 4 Werkzeug und Baumaterial für Profis und Heimwerker. Kostenlose Lieferung möglic

Ascites due to lupus peritonitis: a rare form of onset of

  1. Systemic lupus erythematosus (SLE) is a well recognized cause of an acute abdomen. What is less well recognized is that the underlying pathology can be varied. The computed tomography (CT) and ultrasound appearances of the gall-bladder in a case of SLE serositis are shown
  2. The objective of this study was to describe the prevalence and outcome of disease-related serositis in Chinese patients with systemic lupus erythematosus (SLE). The records of all SLE patients who attended the medical clinics of Tuen Mun Hospital, Hong Kong were retrospectively reviewed
  3. Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that can involve any organ system, and may lead to significant morbidity and even mortality. In this article we review the epidemiology, common clinical features, complications of disease, and briefly address available treatment options. Serositis: Pleuritis—convincing.
  4. Peritoneal serositis with ascites is an extremely rare manifestation of Systemic Lupus Erythematosus (SLE) . It is usually described in established lupus patients and presents with mild to moderate, gradual onset, painless ascites
  5. serositis. PS8:165 Neuropsychiatric damage in deceased patients with systemic lupus erythematosus. I Padjen, M Erceg, M Cerovec, M Mayer, R Stevanovic, B Anic. Lupus Science & Medicine Mar 2018, 5 (Suppl 1) A118-A119; DOI: 10.1136/lupus-2018-abstract.208 . Associates and predictors of pleurisy or pericarditis in SLE
  6. Systemic lupus erythematosus (SLE) is a chronic multisystem disorder that most commonly affects women during their reproductive years. It is characterized by the presence of antinuclear antibodies. In addition to constitutional symptoms, it most frequently involves the skin and joints, although serositis, nephritis, hematologic cytopenias, and.
  7. Clinical Features. Typical butterfly malar rash. Palatal ulcer in SLE. Subacute cutaneous SLE. SLICC Classification Criteria 2012 Requirements: >4 of the following criteria (at least 1 clinical and 1 laboratory) OR biopsy proven lupus nephritis with positive ANA or Anti-dsDNA. Clinical criteria. Malar rash, bullous lupus, photosensitivity

  1. Serositis is a common manifestation and one of the diagnostic criteria of systemic lupus erythematosus. The pathogenesis of serositis in SLE is considered to be a vasculitis of the pleura or peritoneum caused by immune complex deposition and the activation of complements
  2. Compared with SLE patients with IPO, the patients with IPO and ureterohydronephrosis had a significantly higher incidence of gallbladder wall thickening, biliary tract dilatation, and serositis, whereas the patients with ureterohydronephrosis had less mucocutaneous involvement and serositis
  3. Systemic lupus erythematosus (SLE) is a systemic disease of unknown etiology in which immune responses are directed against the body's own tissues. SLE is a disease whose hallmarks are autoantibodies and complement activation. While some autoantibodies are clearly pathogenic (i.e., anti-platelet antibodies, anti-lymphocyte antibodies), others.
  4. g or erosive arthritis was associated only with pleurisy. Pulmonary fibrosis, and gastrointestinal infarc
  5. systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder of connective tissue characterized by autoantibodies that target nuclear antigens, remissions and flares, and highly variable clinical presentation, disease course, and prognosis 1,2,3,4,
  6. ant on immunoXuoresant exa

PBMCs from five patients with serositis without any evidence of SLE, showed a BzATP-stimulated increase of [Ca 2+] i corresponding to 191.8 ± 50.92, significantly higher than that measured in all the other groups of subjects (serositis vs. HC p = 0.008; serositis vs. SLE-NS p = 0.0005; serositis vs. SLE-S p = 0.0016) (Supplementary Figure 4) Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that predominantly affects women of childbearing age. The exact cause is still unknown, but hormonal and immunological features as well as genetic predisposition are considered likely etiological factors. The presentation of the disease is variable but usually characterized. Background/Purpose: Serositis is one of the classification criteria for systemic lupus erythematosus and a common type of extra renal flare. Comparison of associates of pleurisy and pericarditis separately has not been previously done in Caucasians and African Americans. Methods: 2,390 SLE patients in the Hopkins Lupus Cohort were analyzed for demographic, clinical and serologic associates [ Systemic lupus erythematosus is a chronic, multisystem, inflammatory disorder of autoimmune etiology, occurring predominantly in young women. Common manifestations may include arthralgias and arthritis, Raynaud syndrome, malar and other rashes, pleuritis or pericarditis, renal or central nervous system involvement, and hematologic cytopenias The interferons (IFNs) are a large group of functionally related cytokines that mediate host defense against microbes, especially viruses. Since their initial discovery several decades ago, and the reports of increased type I IFN levels in patients with SLE, additional essential roles in other autoimmune diseases, cancer, inflammation, and monogenic disorders have been identified

Serositis related to systemic lupus erythematosus: prevalence and outcome. AU Man BL, Mok CC SO Lupus. 2005;14(10):822. The objective of this study was to describe the prevalence and outcome of disease-related serositis in Chinese patients with systemic lupus erythematosus (SLE) Clinical findings characteristic of SLE, such as oral ulcers, arthritis, nephritis, and hematologic abnormalities, are absent in DM and PM. Patients with DM or PM may also express myositis-specific antibodies, such as anti-Jo-1. (See Clinical manifestations of dermatomyositis and polymyositis in adults . Epidemiology. Serositis is a common manifestation of SLE. In a 10-year and 1,000 patient cohort of SLE, Cervera noted 16% of SLE patients had serositis, including pleuritis and/or pericarditis .The incidence of pericarditis has widely ranged in the literature between 11-54% .Part of the variation in reported data is the difference between symptomatic and asymptomatic pericardial involvement

Of 2104 patients with SLE, 345 were diagnosed with serositis. The prevalence of lupus nephritis (LN), interstitial lung disease and pulmonary arterial hypertension, as well as the presence of leukocytopenia, thrombocytopenia, hypocomplementemia and anti-dsDNA antibodies was significantly higher in patients with serositis (P < 0.05).). Significantly higher SLE disease activity scores were found. Cranial palsies are a very rare feature of SLE. Similarly, peripheral sensory-motor axonal neuropathy is very uncommon in SLE. The combination of the two as the presenting symptoms of SLE is a diagnostic challenge particularly in an elderly male patient with a known diagnosis of sarcoidosis. This case serves to highlight the diagnostic considerations in such a patient

Serositis is one of both ACR and SLICC classification criteria for systemic lupus erythematosus (SLE) and a common type of extra renal flare. However, little is known about clinical or immunological associations of pleurisy or pericarditis The prevalence and risk factors for serositis in patients with systemic lupus erythematosus: a cross-sectional study. Rheumatology international 37 , 305-311 (2017). CAS Article Google Schola Serositis. Specialty. Rheumatology. Serositis refers to inflammation of the serous tissues of the body, the tissues lining the lungs ( pleura ), heart ( pericardium ), and the inner lining of the abdomen ( peritoneum) and organs within. It is commonly found with fat wrapping or creeping fat Background/Purpose: When a complex patient with long term lupus is seen for the first time, there is a need for a readily and commonly available serum marker to graphically indicate the severity and course of their disease.Serum albumin levels are known to reflect SLE activity, especially lupus nephritis, but the utility of this marker to assess longitudinal activity has not been studied Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect almost any organ system. Its presentation and course are highly variable, ranging from indolent to fulminant. A meta-analysis that reviewed the clinical manifestations of childhood-onset and adult-onset SLE found that Raynaud pleuritis and sicca were twice as.

Serositis was associated with higher SLEDAI-2K activity scores (median 18 (IQR 12-25) vs. 10 (4-16), p=0.002) when compared to all patients without serositis. While serositis was associated with dsDNA positivity (77 vs 46%) and higher titers (p=0.01 Pericarditis in SLE is commonly treated with an introduction or increase in dosage of corticosteroids, ranging from low to high doses, up to a methylprednisone pulse. 1,6 -8 The dosage of 0.5 mg/kg/day is recommended 18 and is routinely used in France, a methylprednisone pulse (1 g/day for three days) being recommended for more severe cases. A significant rise in C-reactive protein (CRP) levels in patients with systemic lupus erythematosus (SLE) often reflects a co-existent infection or associated serositis. A number of investigators have proposed that the level of CRP can differentiate between infected and non-infected SLE patients Serositis: Pleurisy and Pericarditis. Pleurisy and pericarditis are the most frequent pulmonary and cardiac manifestations of SLE. The Euro-Lupus (European Working Party on Systemic Lupus Erythematosus) observational cohort found a prevalence of serositis at disease onset of 17% with a cumulative incidence of 36%. 2 Pleuritic chest pain may occur during the course of lupus in up to 60% of. This report presents a pregnant SLE patient complicated by IH, LN and serositis in an unplanned pregnancy that was successfully managed with excellent maternal and fetal outcomes. To the best of our knowledge, this is the first reported case of SLE presenting with these manifestations occurring together during pregnancy. 2. Case presentatio

Malar rash, colloquially known as the butterfly rash, is an acute manifestation of SLE, present in 46-65% of patients (Vilá et al., 2004).The rash is characterized by a symmetrical fixed erythematous maculopapular lesion with slight scale occurring over both cheeks and nose, sparing the nasolabial folds (Figs 3.11, 3.12).The rash is typically transient, lasting from days to weeks. Europe PMC is an archive of life sciences journal literature. Prolactin and autoimmunity: hyperprolactinemia correlates with serositis and anemia in SLE patients TY - JOUR. T1 - Prolactin and autoimmunity. T2 - Hyperprolactinemia correlates with serositis and anemia in SLE patients. AU - Orbach, Hedi. AU - Zandman-Goddard, Gisel The aim of this study was to investigate the role of P2X7R and NLRP3-inflammasome in SLE. Methods: Forty-eight SLE patients, 16 with (SLE-S) and 32 without (SLE-NS) history of serositis, and 20 healthy control (HC) subjects were enrolled. Demographic, clinical, and therapeutic data were collected

Serositis is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity Start studying SLE, Scleroderma, Sjorens, Sarcoidosis. Learn vocabulary, terms, and more with flashcards, games, and other study tools SUMMARY. The imaging appearances of a case of systemic lupus erythematosus, which manifested initially as a serositis, is described. Barium small bowel study showed segments of spiculation with tethering, angulation, and obstruction. On computed tomography there was ascites and segments of asymmetrical thickening of small bowel wall were observed Serositis: Should get better when sle gets controlled. But it's s chronic disease so there's a chance of recurrence. But it's s chronic disease so there's a chance of recurrence. 4.9k views Reviewed >2 years ag Chinese SLE Treatment and Research group (CSTAR) registry VII: prevalence and clinical significance of serositis in Chinese patients with systemic lupus erythematosus. Lupus 2016 ; 25 : 652 - 657

Serositis: Symptoms, Lupus, Autoimmune, Other Causes, and

systemic lupus erythematosus (SLE) to inform serositis, pulmonary involvement, sicca symptoms, and musculoskeletal manifestations. 4 Natural history and course SLE is a chronic disease of variable severity with a waxing and waning course, with signifi cant morbidity that can b Systemic lupus erythematosus (SLE), an autoimmune disorder which primarily affects women (10:1 female to male ratio), may affect virtually any organ.1 Predominant manifestations include non-deforming arthritis, serositis, photosensitivity, renal, haematological, and central nervous system involvement. Various laboratory abnormalities have been described in SLE, most commonly high titre. Hi purpletop ive been in a flare for as long as i can remember, the rhumt seems to think its now adding serositis mine is swelling of the abdominal lining and abdominal organs, i thought lupus was bad enough on its own but crushing pain and vomiting nearly everyday and still trying to work is totally a up hill battle..going to start a round of steriod injections on monday and hopefully have. Many people with SLE find that the ultraviolet rays from the sun or fluorescent lights make their condition worse. Other symptoms may include an unexplained fever, muscle aches, loss of appetite, hair loss, a butterfly-shaped rash across the nose and cheeks (malar), sores in the nose or mouth, serositis, seizures and a lower than normal number. Systemic lupus erythematosus (SLE) is a rheumatic disease characterized by autoantibodies directed against self-antigens, immune complex formation, and immune dysregulation, resulting in damage to essentially any organ. The disease can affect, for example, the kidneys, skin, blood cells, and nervous system

Imaging Findings in Systemic Lupus Erythematosu

Systemic lupus erythematosus (also known as lupus) is a chronic, relapsing-remitting autoimmune disease characterised by autoantibody production. It may present at any stage of life, but is most common in women of childbearing age, with a female to male ratio of 9:1. Serositis - typical pleurisy for more than one day, pleural effusions,. Systemic lupus erythematosus (also called SLE, or lupus) is an autoimmune disease of the body's connective tissues.Autoimmune means that the immune system attacks the tissues of the body. In SLE, the immune system primarily attacks parts of the cell nucleus. SLE affects tissues throughout your body of SLE were more common in the group. The diagnosis of SLE was established within 3 months prior to the thoracentesis in four of eight patients. In six of the patients with SLE, the pleural effusions resulted from lupus pleuritis. Symptoms consistent with active serositis were noted in all and five patient Drug-induced lupus erythematosus (DILE) is a variant of lupus erythematosus that resolves within days to months after withdrawal of the culprit drug in a patient with no underlying immune system dysfunction. DILE can arise months to years after exposure to drugs prescribed to treat various medical conditions (eg, antihypertensives, antibiotic..

Systemic Lupus Erythematosus: ACR Criteria Diagnosis

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by antibodies to nuclear and cytoplasmic antigens, multisystem inflammation, protean clinical manifestations, and a relapsing and remitting course. More than 90% of cases of SLE occur in women, frequently starting at childbearing age. See the image below Systemic lupus erythematosus is a chronic autoimmune inflammatory connective tissue disorder that can involve joints, kidneys, skin, mucous membranes, and blood vessel walls. Problems in the joints, nervous system, blood, skin, kidneys, gastrointestinal tract, lungs, and other tissues and organs can develop Systemic lupus erythematosus (SLE) is a serious chronic autoimmune disease, which can involve multiple organs and cause systemic damage. Although the treatment of SLE has been improving, most patients still go through alternating courses of flare and remission. anemia associated with SLE, and serositis as dependent variables and using age.

Lupus

C‐reactive protein and systemic lupus erythematosus

Systemic Lupus Erythematosus Nutrition Guide for Clinician

Chinese SLE Treatment and Research group (CSTAR) registry VII: prevalence and clinical significance of serositis in Chinese patients with systemic lupus erythematosus. J Zhao, W Bai, P Zhu, X Zhang, S Liu, L Wu, L Ma, L Bi, X Zuo, L Sun, C Huang, X Tian, M Li, Y Zhao, X Zeng. Serositis related to systemic lupus erythematosus: prevalence and outcome. Lupus 2005 ; 14 : 822 - 826 . doi: 10.1191/0961203305lu2187oa OpenUrl CrossRef PubMe Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder with involvement of multiple organs. Various forms of serositis, including pleural effusion, pericardial effusion, and ascites, may be found during the course of SLE. Peritoneal involvement by ascites is common in the initial presentation of SLE. However, chylous ascites is uncommon in SLE patients ObjectivesTo investigate both the prevalence and clinical characteristics of serositis in Chinese patients with systemic lupus erythematosus (SLE) in a large cohort in the Chinese SLE Treatment and.. Serositis is an inflammation of the serous tissues of the body, the tissues that line the lungs (pleura), the heart (pericardium) and the inner lining of the abdomen. It also refers to internal organs. It is commonly found with fat wrapping. Another type of serositis related to lupus is pericarditis

Systemic Lupus Erythematosis

Imaging Findings in Systemic Lupus Erythematosus

Systemic lupus erythematosus Radiology Reference Article

Background/Purpose: ESR is applied for monitoring disease activity in SLE. It is known to be influenced by age and infections. We aimed at evaluating how ESR correlates with commonly applied disease activity parameters and how infections influence these results. Methods: Retrospective analysis of laboratory parameters, clinical activity, infection and serositis in consecutive SLE patients. Systemic Lupus. Erythematosus Systemic Lupus Erythematosus Aetiology Pathogenesis Clinical features Investigations Diagnostic criteria Treatment An autoimmune disease characterized by immune responses against endogenous nuclear antigens, due to impaired tolerance to them.. Spectrum of Antibodies in SLE Non-Specific a) Ab against nuclear components b) Ab against cell components Specific a) Ab.

Lupus Erythematodes Selbsthilfegruppe Darmstadt

A young lady with seronegative systemic lupus erythematosu

Objectives In this study, we aimed to examine and analyze liver abnormalities among patients with systemic lupus erythematosus (SLE), including both newly diagnosed patients and those being followed up, as well as the prevalence of lupus hepatitis. Methods This was a prospective observational study. Clinical data, liver function tests (LFTs), and the findings from the ultrasonography of the. This study is a multi-center, double-blinded, randomized, placebo-controlled, phase 2 clinical trial to assess the safety and efficacy of sirolimus in patients with active systemic lupus erythematosus despite receiving standard background therapy. Six large rheumatological referring centers across from China will participate in the study Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease with the potential to cause significant morbidity and mortality in affected patients. Clinical heterogeneity, in terms of breadth of organ involvement and disease activity over time, adds to the complexity of disease management and measurement

Basics of SLEOurMedicalNotes: Systemic Lupus Erythematous (SLE)The Many Faces of Lupus: An Approach to the Assessment of

SLE-DAS. 1. Neuropsychiatric involvement. Neuropsychiatric features included in the SLICC classification criteria for SLE, including recent onset of seizure, psychosis, organic brain syndrome, acute confusional state, SLE retinal changes, peripheral neuropathy myelopathy, lupus headache, cerebrovascular accident and aseptic meningitis. 2 S- serositis (inflammation of the lining of body cavities) O-oral ulcers A-arthritis P- photosensitivity B-blood (ab that formed against blood cells -> decreased count) R- renal failure A- ANA (sensitive but non specific for lupus) I- immune markers (look if ana + and includes double stranded DNA and anti smith ab) N- neurologic (encephalitis POM 2 Exam 4: SLE. Affect any organ system (autoimmune connective tissue disease) (MSK, cutaneous, and renal) Nice work! You just studied 64 terms! Now up your study game with Learn mode In an Afro-Caribbean cohort of SLE patients, rash, alopecia, mouth ulcers, serositis, neurological, joint and renal involvement were significantly associated with the presence of anti-Sm. 39 Thompson et al also found that anti-Sm antibody has an association with both the malar rash and haematological and renal involvement among SLE patients. 40. Other organ or system involvement in systemic lupus erythematosus. 2016 2017 2018 2019 2020 2021 Billable/Specific Code. M32.19 is a billable/specific ICD-10-CM code.