Home

Spironolactone hirsutism Reddit

coming off spironolactone : Hirsutism - reddi

I have hirsutism and also suffer from extreme pelvic pain after my period. Last year, I decided to give up on the pill, despite the fact that it will make my hirsutism worse, thanks to Covid and WFH! I have had irregular periods since then but I feel like I'm more in touch with my body I was prescribed spiro in September 2020 for acne and hirsutism. I also have high blood pressure so it was a bonus for that too. I was on 25mg for two weeks then 50mg for a month and since then I've been taking 100mg daily. I have zero side effects but I'm also not sure it's actually doing anything PIP: Spironolactone (Aldactone) appears to have potential as a treatment for androgen-excess syndromes, including hirsutism. In both men and women, spironolactone decreases the rate of testosterone production and increases its metabolic clearance. The 1st indication that this agent has an effect on hirsutism was serendipitous--an incidental finding in a patient who was being treated for. User Reviews for Spironolactone to treat Hirsutism. Also known as: Aldactone, CaroSpir. Spironolactone has an average rating of 6.6 out of 10 from a total of 48 ratings for the treatment of Hirsutism. 54% of users who reviewed this medication reported a positive effect, while 27% reported a negative effect. Filter by condition Spironolactone has the potential to raise cortisol levels in some women to an alarming degree. The health problems that rise from elevated cortisol can be very destructive. I'm posting this to let you know as you make your decisions on hair loss treatments. Spironolactone did not regrow my hair

r/Hirsutism - Day one of being on spironolactone - reddi

The mechanism of action of this drug is mainly via a peripheral anti-androgenic effect but it may also result in decreased androgen production. The results of a number of clinical studies are discussed with particular reference to the side effects of spironolactone. Guidelines for treatment of hirsutism and female mature age acne are given Spironolactone for PCOS Hirsutism and Acne: The Final Verdict. Spironolactone has been used for more than 30 years for treating PCOS hirsutism and acne. A few long-term studies do indicate that this drug is safe. However, it is seen that some women do not complete the treatment course due to the side effects

However, studies have shown that spironolactone added to oral contraceptives delivers better results. When used for hirsutism, 50 - 200 mg daily in one to two divided doses is better than placebo and better than oral contraceptives alone. 6) Female pattern hair loss. Female pattern hair loss is characterized by thinning on the crown In PCOS patients, the mean score for hirsutism after 12 months was significantly lower with CPA (12 ± 1) than with spironolactone (16 ± 1). Testosterone levels did not change with spironolactone; with CPA there was a decrease from baseline in PCOS (47% and 51%, 6 and 12 months) and IH patients (31% and 30%) The most commonly used anti-androgen for treating hirsutism is spironolactone (Aldactone, CaroSpir). The results are modest and take at least six months to be noticeable. Possible side effects include menstrual irregularity. Because these drugs can cause birth defects, it's important to use contraception while taking them. Topical cream Spironolactone, or Aldactone, is a prescription diuretic that helps restore the balance of sodium and potassium in the body and is used for high blood pressure and heart disease. This drug also can suppress the hormone, testosterone. Given its antiandrogen activity, spironolactone has several off-label uses including: Hormonal acne

Spironolactone : PCOS - reddit

Spironolactone, in daily doses of 50-200 mg, blocks androgen receptors. Spironolactone also decreases testosterone production, making it additionally effective for hirsutism. The side effects of Spironolactone if taken primarily to encourage HEAD hair growth or discourage FACIAL hair growth will mainly be due to lower testosterone What is spironolactone? Spironolactone (Aldactone) is a diuretic (a water pill), which means it is a drug that removes fluid from your body. It can be used to treat acne in women by targeting the hormonal causes of acne. Though it's effective for treating acne in women, spironolactone isn't typically used to treat acne in men because it decreases testosterone and can cause unwanted. Aldactone (Spironolactone) received an overall rating of 8 out of 10 stars from 326 reviews. See what others have said about Aldactone (Spironolactone), including the effectiveness, ease of use and side effects Lara, In the past I took SawPalmetto (at a high dose, 1000 mg per day.) and it lowered my estrogen and made me extremely depressed. Now that I have studied more I want to try DIM for PCOS related hirsutism and hair loss, but am terrified of experiencing the same low estrogen effects Key Words: Idiopathic hirsutism, flutamide, spironolactone, Diane 35 Hirsutism, which affects 5%-15% of reproductive-aged women, is a disorder that is the result of excessive androgen production by the human body or of increased skin sensitiv-ity to androgens (1-3). In most patients, hirsutism should b

Spironolactone is used to treat heart failure, high blood pressure (hypertension), or hypokalemia (low potassium levels in the blood). Spironolactone also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome PIP: 54 patients, aged 21-51, treated with 200 mg/day spironolactone for hirsutism and/or acne, were studied to determine the kinds and severity of side effects and the ameliorating effect of oral contraceptive on the side effects. Spironolactone is used to treat hirsutism and acne because of its antiandrogenic effects, brought about through suppression of gonadal androgen production by. DOSAGES. The dosage of spironolactone for acne is 25-200 mg/day in one to two divided doses. A study that used 50 mg spironolactone twice a day on Days 5 through 21 of women's menstrual cycle had a high rate of success with low incidence of side effects ( Harper, 2006 ). The dosage of spironolactone for hirsutism is 50-200 mg/day in one to two.

Lo Loestrin Fe or Spironolactone for Hirsutism? : PCO

More recently, it has been used to treat hirsutism in women [9.10.]. Using spironolactone to treat hirsutism may sound contradictory, but body hair (e.g. chest, face, axilla, pubis, etc.) is promoted by testosterone and since spironolactone is a potent anti-androgen, it s successfully used to eliminate unwanted hair on the body[11] D J Evans, C W Burke, Spironolactone in the Treatment of Idiopathic Hirsutism and the Polycystic Ovary Syndrome, Journal of the Royal Society of Medicine, 10.1177/014107688607900806, 79, 8, (451-453), (2016) In 2010, I was put on 100 mg spironolactone for severe hirsutism, and it worked wonders for me. Last June, I came off the birth control pill after my husband had a vasectomy, thinking it was the right thing to do. I can not tell you how horribly my body responded. I continued the monotherapy of 100 mg of Spionolactone each day, which caused a. spironolactone is a good (possibly the best/most studied/most recommended) topical androgen blocker available. (I know, RU the wonder cream cooked up in small batches and mailed from behind the iron curtain and Fluradil both exist, but finding genuine RU is a problem, and finding actual studies on either is difficult to impossible.... couple that with the cost and spironolactone looks good.

was on 50mg BID spironolactone for hirsutism (no PCOS, due to mildly elevated testosterone)...it wasn't working so my doctor increased it to 100mg BID. i think the hair growth is slowing down somewhat but i do feel a little lightheaded in the morning. will keep an eye on it though, having hair on my face is such a killer Spironolactone is the most commonly used, off-label anti-androgen for the treatment of female AGA and hirsutism. Spironolactone is a potassium-sparing diuretic and structural antagonist of aldosterone (van Zuuren et al., 2012a) and acts as an androgen antagonist by competitively blocking androgen receptors as well as inhibiting ovarian androgen. Spironolactone has an average rating of 7.2 out of 10 from a total of 576 ratings on Drugs.com. 63% of users who reviewed this medication reported a positive effect, while 21% reported a negative effect. Reviews may be moderated to correct grammar/spelling or remove inappropriate language

The clinical efficacy of a combination of spironolactone and an oral contraceptive pill (Conova 30) was assessed in 23 patients presenting with hirsutism of whom 20 completed 6 months of treatment. Of the 20 patients, 16 showed improvement on objective (Ferriman & Gallwey hair score) and subjective assessment Spironolactone's two main off-label uses are for hirsutism and acne (especially hormonal acne, as the body parts affected by this are where testosterone makes hair grow — the chin, back, and chest). These conditions can occur on their own or as part of a syndrome like the one I have: polycystic ovary syndrome (PCOS) Julie Brown, Cindy Farquhar, Olivia Lee, Robyn Toomath, Ruth G Jepson, Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne, Cochrane Database of Systematic Reviews, 10.1002/14651858.CD000194, (1996) Abstract. Sixteen women with hirsutism used spironolactone, 100 mg daily without interruption, plus norethindrone (1 mg) and ethinyl estradiol (35 mg) for 21 of each 28 days. Clinical improvement occurred in 11 of the 16 patients and also in an additional patient when the dose of spironolactone was increased to 200 mg daily

Oral spironolactone therapy for female patients with acne, hirsutism or androgenic alopecia. B.M. Burke, The Department of Dermatology, The General Infirmary, Leeds LS1 3EX, U.K. Search for more papers by this author In patients who are taking spironolactone for off label indications such as hair loss or hirsutism, one should be looking for alternatives that also possess antiandrogen activities. Eplerenone has been developed specifically to have much less affinity for the androgen or progestin receptors, so its use is unlikely to offer equivalent benefits Spironolactone is a medication usually used for fluid retention but sometimes used to treat hair loss. We'll go over the types of hair loss it works best for, how it works, and what you can. WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Spironolactone is known to have antiandrogenic features and agonist activity at progesterone receptors, which are responsible for several of its hormonal.

This tells us that when either flutamide or spironolactone was in association with a triphasic oral contraceptive (OC) pill, the group that used flutamide had a 30% more decrease in total acne and seborrhea scores, 70% more decrease in hirsutism scores, and a 80% more decrease in hair loss scores that the group that took spironolactone I added spironolactone (200mg/day) about 6 months ago to my regimen (proscar, minoxidil, RU & nizoral). I continue to lose hair but I think the spironolactone has slowed down the rate of loss. I want to take the next step and add to this regimen so I've ordered Cyproterone Acetate. I intend on.. Hirsutism in polycystic ovarian syndrome (PCOS), consequent to elevated androgen levels leads to significant cosmetic and psychological problems. Recent research in Turkey has shown that spearmint tea has antiandrogenic properties in females with hirsutism. No research has yet been undertaken to ass The treatment is also sometimes prescribed in other cases of hirsutism. Although other, more proven treatment methods are available, Spironolactone is prescribed off-label for Hirsutism on a semi-regular basis. Heart Failure. In 1999, researchers tested Spironolactone on 1,663 patients with heart failure. 822 received a daily dose spironolactone

Spironolactone experiences : PCOS - reddit

Both caused significant, but limited, improvement in hirsutism. Although promising, further studies with finasteride are needed to verify its effectiveness as a treatment for hirsutism. Such studies will also provide a better understanding of the relative contribution of 5 alpha-reductase isoenzymes to hirsutism User Reviews for Spironolactone to treat Alopecia. Also known as: Aldactone, CaroSpir. Spironolactone has an average rating of 7.3 out of 10 from a total of 45 ratings for the treatment of Alopecia. 60% of users who reviewed this medication reported a positive effect, while 16% reported a negative effect. Filter by condition Results: Both finasteride and flutamide induced a significant decrease in the hirsutism scores and hair diameters at the end of 12 months. Finasteride reduced the Ferriman-Gallwey score by 31.4% in the PCOS cases and by 34.2% in the idiopathic hirsutism cases, and hair diameter by 27.0-34.1% in PCOS and by 29.6-37.9% in idiopathic. To investigate the effects of spironolactone on serum lipids in women with hirsutism over a 3-month period. METHODS In a prospective setting, 27 hirsute women (20 with polycystic ovary syndrome and seven with idiopathic hirsutism) with a mean age of 23.0 ± 5.1 years were studied at baseline and 3 months after receiving a daily dose of 100 mg.

Spironolactone experiences? : PCOS - reddit

spiro nausea : Spironolactone - reddit

Abstract Spironolactone is a pharmaceutical that in humans is used to treat conditions like hirsutism, Reddit; Wechat; Abstract. Spironolactone is a pharmaceutical that in humans is used to treat conditions like hirsutism, various dermatologic afflictions, and female-pattern hair loss through antagonism of the androgen receptor.. Aldactone is a prescription medicine used to treat the symptoms of high blood pressure (hypertension), low potassium levels (hypokalemia) and heart failure. Aldactone may be used alone or with other medications. Aldactone belongs to a class of drugs called Aldosterone Antagonists, Selective, Diuretics, Potassium-Sparing Spironolactone. Spironolactone is a diuretic with anti-androgen properties. It can be helpful to explain to women that they have both estrogens (girl hormones) and androgens (boy hormones), and that in most women with FPHL these levels are NORMAL. 7 However, their follicles are genetically more sensitive to circulating levels of androgens, specifically in the frontal 1/3-2/3 of the scalp (or.

Use of spironolactone in treatment of hirsutis

  1. The recommended dosage for Saw Palmetto extract is a 400mg capsule/day, or 1 tsp. liquid extract/day, post meal. Like most herbal treatments, saw palmetto takes time to show positive results. It can take up to 6 weeks before you see any improvements in your male pattern baldness and excess body hair. Discuss continued usage with your PCOS.
  2. Spironolactone is an acne treatment prescribed by dermatologists. Find out how spironolactone improves the appearance of hormonal acne, side effects, and more
  3. If one hesitates to use oral finasteride, topical finasteride, topical spironolactone or ketoconazole shampoo is a better option. References. 1. Battmann, T., et al., RU-58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism. J Steroid Biochem Mol Biol, 1994
  4. Spironolactone. Spironolactone is a potassium-sparing medication used as a diuretic medication for heart failure, liver disease and high blood pressure. However, it has also been found useful for hirsutism, acne and seborrhoea because it has anti-androgenic properties. Spironolactone mainly works by blocking androgen receptors
  5. Spironolactone is a synthetic steroid structurally related to aldosterone. Since the serendipitous discovery 20 years ago that spironolactone given to a woman for polycystic ovary syndrome (PCOS) and associated hypertension also improved hirsutism, it has been used as a primary medical treatment for hirsutism
  6. Spironolactone weight loss and weight gain misconceptions are a genuine concern for many. Strictly speaking, Spironolactone is not a weight loss pill or supplement. However, some users of this prescription medicine claim to have achieved weight loss results with it. On the contrary, few others have reported weight gain after having Spironolactone
  7. al hair growth on a woman's body. This hair growth occurs in androgen-sensitive sites, the most common of which are the chin sideburns, above the upper lip, and chest (Figure 1). The diagnosis is generally made clinically. A detailed history and physical exa

Hirsutism Some people with PCOS take a medication called finasteride to treat hirsutism. Combining this with spironolactone can sometimes control excessive hair growth Spironolactone is an 'off-label' drug which means it is not licensed in the UK for the treatment of acne, explains Dr Anjali Mahto, consultant dermatologist and author of The Skincare Bible. Symptoms of hirsutism. The main symptom of hirsutism is unwanted hair growth on a woman's face, chest, and back. This thick, dark hair is different from the normal, fine baby hair on other parts of the body. Other symptoms of hirsutism may include: Acne. Abnormal menstrual periods

Spironolactone User Reviews for Hirsutism - Drugs

  1. Aldactone (spironolactone) is a potassium-sparing diuretic that removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease.It also can be used in combination with other drugs to treat diuretic-induced low potassium (hypokalemia) and high blood pressure.Aldactone also is used to counteract the effects of excessive adrenal aldosterone production.
  2. Aldactone spironolactone is a medication that's used to treat many different disorders, from high blood pressure to fluid retention spironolactone is also teratogenic off-label to treat female-pattern hair steroid and hirsutism. Can you get aldactone 25mg to united states. //www.reddit.com effective if taken with food
  3. RESULTS: After only 6 months of therapy, flutamide caused a maximal reduction in the hirsutism score to a value within almost normal range; during the same period, spironolactone caused only a 30% reduction of the hirsutism score. Whereas flutamide caused a dramatic (80%) decrease in total acne, seborrhea, and hair loss score after only 3.
  4. Spironolactone (pronounced: spi-ro-no-lac-tone) is a diuretic or water pill that's prescribed for people who have high blood pressure and for those who have swelling due to extra fluid, but it also has other benefits. Spironolactone is often prescribed for young women with PCOS who are taking oral contraceptive pills and who are hirsute (have extra..
  5. I am interested in the studies done on the effects of anti androgens against hirsutism. I'm currently using fluridil and keep my sanity by learning as much as i can

User Reviews for Spironolactone to treat Acne. Also known as: Aldactone, CaroSpir. Spironolactone has an average rating of 7.4 out of 10 from a total of 385 ratings for the treatment of Acne. 65% of users who reviewed this medication reported a positive effect, while 19% reported a negative effect. Filter by condition Spironolactone induces gynecomastia by decreasing testosterone production, increasing peripheral conversion of testosterone to estradiol, and displacing estradiol from sex hormone-binding globulin. Gynecomastia is a well-described adverse effect of spironolactone and is related to dose and duration of treatment; overall prevalence is 10% Hi, I was taking Diane 35 and Spirolactone for PCOS when I was 17. I have always had mild hirsutism facial hair, stomach hair, lower back/bum hair and even some hair on my nipples and between my breasts. I haven't had a weight problem though. I was on Diane 35 until it was recalled I have been in touch with you in the past regarding my hirsutism and use of birth control pill (came off Feb 2016) and spironolactone (came off June 2016) to control it. I have your book, and per recommendation to reduce hirsutism, I have added berberine to my daily supplementation, dosing at 500 mg per day

Spironolactone and Elevated Cortisol My 4 Year Experience

  1. Advantages: • Lost quite a bit of weight and didn't even notice until last week (after being on it for 7 weeks). • Acne (I mainly had blackheads and milia/small bumps not larger acne) is 97% clear and healed. I get flare ups from the ingrown hairs/ peach fuzz on my face - but I'm getting laser in a few weeks
  2. Female facial hair growth is caused by a number of factors, including polycystic ovary syndrome (PCOS), and removal isn't the only response. These women with PCOS decided to celebrate their beards.
  3. 39.32 Select the diuretic that can cause gynaecomastia, hirsutism and menstrual disturbance as a side effect on long-term use: A. Amiloride B. Spironolactone C. Metolazone D. Acetazolamide 39.33 Amiloride inhibits K+ excretion in the distal tubules and collecting ducts by blocking: A. Electrogenic K+ channels B. Electrogenic Na+ channel
  4. Background: Physicians are beginning to use finasteride as treatment for hair loss, hirsutism, and various other dermatologic conditions in women. However, the reported efficacy and use of finasteride in the female population varies widely. The purpose of this study is therefore to better define the efficacy and use of finasteride in women and identify research gaps that require further.
  5. Cyproterone acetate is an anti-androgen drug. Adverse effects that have been reported with its use include weight gain, depression, fatigue, breast symptoms and sexual dysfunction. The review of trials found that cyproterone acetate appears to have a similar impact on hirsutism as other drugs used for hirsutism caused by excessive androgen
  6. B5, the anti-stress factor.. In addition to treating the underlying driver of your PCOS, you may also require a natural anti-androgen supplement. For information about the 4 types of PCOS and their treatments, see Chapter 7 of Period Repair Manual

SPIRONOLACTONE THERAPY IN HIRSUTISM AND ACNE - Callan

  1. oxidil,30 and, in these women, spironolactone (Aldactone) 100 to 200 mg daily may slow the rate of hair loss.10, 31 Women with.
  2. Spironolactone is an aldosterone antagonist and is used as a potassium-sparing diuretic. In alopecia, it acts by reducing the levels of total testosterone and completely blocking androgen receptor activity in target tissues. It is approved in Australia for the treatment of female hirsutism
  3. Many cases of acne are hormonal in nature, meaning that they occur in adolescent girls and women and are aggravated by hormonal fluctuations such as those that occur during the menstrual cycle or in the setting of underlying hormonal imbalances as seen in polycystic ovary syndrome. For these patients, antihormonal therapy such as spironolactone is a valid and efficacious option
  4. imizing systemic side effects
  5. Spironolactone (orally) does have potential side-effects (the most serious being a build-up of potassium which could be lethal) and should not be taken lightly. In one study group, a 25mg or 50mg dose (cant remember which) caused development gynecomastia in 10% of men (man-tits). Oral spironolactone also has all the other side-effects possible.
  6. al hair leaning towards the pubic region. Google the phrase and results range from.

Spironolactone For PCOS: Benefits And Side Effect

In studies examining spironolactone use in the treatment of hirsutism, no change in baseline testosterone levels has been found (although cyproterone acetate, a progestational compound, did lead to a decrease). 9,10 We found no difference in testosterone levels at equivalent levels of estradiol when spironolactone was part of the regimen. Hirsutism in women. Hirsutism in women is the problem of having too much hair on the face or body. In women with hirsutism, the hair is coarse and pigmented, and grows in areas where men tend to grow hair (lower face, chest, back and abdomen). For each woman, it is a matter of personal preference how much hair she considers to be too much, and. PCOS and Hirsutism What is hirsutism? Hirsutism is excess facial and body hair growth. Because facial hair growth varies from person to person and there are ethnic differences, I recommend speaking to a dermatologist, gynecologist, or reproductive endocrinologist to determine the severity of the hair growth you're experiencing The Strange Predicament of RU58841. RU-58841 MezogenRX. 2% Formulation. In the early 1990s, scientists in France synthesized a new topical anti-androgen called RU58841 (or RU-58841). This product was effective at tackling various androgen related disorders, including hair loss, acne and hirsutism. Since that time, a few favorable studies have.

7 Uses for Spironolactone, From Heart Failure to Hair Loss

User Reviews for Spironolactone to treat Alopecia (Page 2) Also known as: Aldactone, CaroSpir. Spironolactone has an average rating of 7.3 out of 10 from a total of 45 ratings for the treatment of Alopecia. 60% of users who reviewed this medication reported a positive effect, while 16% reported a negative effect. Filter by condition Hirsutism is when hair grows in unusual areas of a woman's face and body, such as the face or back, or at an unusual density and thickness. It usually occurs due to a hormone imbalance or other. I've created this secondary blog to talk about my experience with hirsutism, and amongst other things, and about finally starting treatment for it. I am a 22 year old female from Long Island, New.. Definition. Hirsutism is a condition where a female develops a male pattern growth of thick, pigmented androgen dependant terminal hair. This is to be differentiated from overgrowth of non-sexual (vellus) hair, which is the fine, lightly pigmented hair covering most areas of the body during the prepubertal years and is known as hypertrichosis I take spironolactone for acne, fish oil and a multi. None of these are new. MD. Thanks for returning to HCM with more information on you problem. From your medication list I would say that the spironolactone can cause elevated potassium levels and this can cause some mouth and taste changes

Spironolactone as a single agent for long‐term therapy of

a type of stomach irritation called gastritis. breast pain. absence of menstrual periods. irregular periods. a problem with menstrual periods. hair loss. leg cramps. drowsiness. fever What marketing strategies does Hirsutism use? Get traffic statistics, SEO keyword opportunities, audience insights, and competitive analytics for Hirsutism Hair & acne - management & treatment. Excess hair on the face and body ('hirsutism'), hair loss from the scalp ('alopecia') and acne are often symptoms of PCOS and caused by high levels of androgen hormones. These symptoms often cause considerable distress for those with PCOS and it is important to know that treatments are available

Hirsutism - Diagnosis and treatment - Mayo Clini

Bicalutamide is an anti-androgen which is used mainly in the treatment of prostate cancer but can also be used to treat hirsutism, or as a component of hormone therapy in feminizing HRT, among other uses. It is nonsteroidal anti-androgen and a selective/pure antagonist of the androgen receptor.It has no other hormonal activity and does not lower androgen levels Generic Name Spironolactone DrugBank Accession Number DB00421 Background. Spironolactone is a potassium sparing diuretic like eplerenone that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention. 8.Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of. Spironolactone has been used for more than 25 years as an antiandrogen in the treatment of acne and hirsutism. The drug has had success in treating adult women with acne, but side effects are. Spironolactone, popularly called spiro in the trans community, is a diuretic most commonly used to lower blood pressure via its effect on the water- and salt-regulating hormone aldosterone, causing the body to absorb less sodium and more potassium. and John F. Hennessy. 1978. Spironolactone Therapy for Hirsutism in a.

Spironolactone and Acne: What It Is, Why It's Bad, And Why

Key Difference - Polycystic Ovaries vs PCOS PCOS or Polycystic ovarian syndrome is an ovarian disorder characterized by multiple small cysts within the ovary and by excess androgen production from the ovaries. On the other hand, polycystic ovary can be defined as an ultrasound scan image of the ovaries that appears to be polycystic Clinical uses include hyperaldosteronism, hypertension, heart failure, and female hirsutism (spironolactone). The Na + channel blockers can be used as adjuncts to other diuretics. Amiloride is used for the treatment of diabetes insipidus. Adverse effects include acidosis, hyperkalemia, azotemia, gynecomastia and libido changes (spironolactone. Spironolactone is the most commonly used androgen blocker in the U.S. Spironolactone is a potassium sparing diuretic, which in higher doses also has direct anti-androgen receptor activity as well as a suppressive effect on testosterone synthesis.[6] Doses of 200mg daily in non-transgender women being treated for hair loss have been described as.

It appears that spironolactone also results in decreased sebum production and is effective in the treatment of acne in PCOS. Lower doses (50-100 mg/d) appear to be effective when compared with the treatment of hirsutism and alopecia. As spironolactone is a potassium-sparing diuretic, there is a theoretical risk of hyperkalemia Hirsutism and Polycystic Ovary Syndrome. (PCOS) Hirsutism is the excessive growth of facial or body hair on women. Hirsutism can be seen as coarse, dark hair that may appear on the face, chest, lower abdomen, back, upper arms, or upper legs. Hirsutism is a symptom of medical disorders associated with the hormones called androgens Table 1: Laboratory values of patient during visits. Case Discussion. Spironolactone is a potassium sparing mineralocorticoid receptor antagonist (MRA) which acts on the distal tubules and collecting ducts of the kidneys and antagonizing the effect of aldosterone, thereby causing inhibition of sodium and chloride reabsorption, and potassium secretion in the distal tubules